Macrophages Promote Resistance to Checkpoint Inhibitors [News in Brief]

A study in mice suggests that macrophages produce resistance to checkpoint inhibitors by removing anti–PD-1 antibodies from T cells. Fc receptors on macrophages bind to the Fc domain on the antibodies. Blocking this interaction with other antibodies produced dramatic tumor shrinkage in mice.
Source: Cancer Discovery - Category: Cancer & Oncology Tags: News in Brief Source Type: research