Targeting the Noncoding Genome: Superenhancers Meet Their Kryptonite [In the Spotlight]

In this study, McKeown and colleagues carried out a genome-wide characterization and stratification of the enhancer landscape in acute myeloid leukemia (AML). The authors' analysis led to the discovery of a novel RARA superenhancer found in a subset of patients with AML, rendering these leukemia cells highly sensitive to SY-1425, a highly potent RARA agonist able to induce myeloid differentiation in these high-expressing RARA AML subtypes. Cancer Discov; 7(10); 1065–6. ©2017 AACR. See related article by McKeown et al., p. 1136.

http://cancerdiscovery.aacrjournals.org/cgi/content/short/7/10/1065?rss=1

Source: Cancer Discovery - October 2, 2017 Category: Cancer & Oncology Authors: Wang, E., Aifantis, I. Tags: In the Spotlight Source Type: research