De Novo Thrombotic Microangiopathy after Kidney Transplantation

Thrombotic microangiopathy (TMA) is a serious complication of transplantation that adversely affects kidney transplant recipient and allograft survival. Post-transplant TMA is usually classified into two categories: 1) recurrent TMA and 2) de novo TMA. Atypical hemolytic uremic syndrome (aHUS) resulting from dysregulation and over-activation of the alternate complement pathway is a rare disease but the most common diagnosis associated with recurrence in the allografts. De novo TMA, on the other hand, represents an overwhelming majority of the cases of post-transplant TMA and is a substantially more heterogeneous entity than recurrent aHUS.

Source: Transplantation Reviews - November 4, 2017 Category: Transplant Surgery Authors: Neetika Garg, Helmut G. Rennke, Martha Pavlakis, Kambiz Zandi-Nejad Tags: Review article Source Type: research