Loss of microRNA-22 prevents high fat diet induced dyslipidemia and increases energy expenditure without affecting cardiac hypertrophy

In this study, we examined the role of miR-22 in the cardiac and metabolic alterations promoted by high fat (HF) diet. We found that loss of miR-22 attenuated the gain of fat mass and prevented dyslipidemia induced by HF diet, although the body weight gain, or glucose intolerance and insulin resistance did not seem to be affected. Mechanistically, loss of miR-22 attenuated the increased expression of genes involved in lipogenesis and inflammation mediated by HF diet. Similarly, we found that miR-22 mediates metabolic alterations and inflammation induced by obesity in the liver. However, loss of miR-22 did not appear to alter HF diet-induced cardiac hypertrophy or fibrosis in the heart. Our study therefore establishes miR-22 as an important regulator of dyslipidemia and suggests it may serve as a potential candidate in the treatment of dyslipidemia associated with obesity.

Source: Clinical Science - November 3, 2017 Category: Biomedical Science Authors: Diniz, G. P., Huang, Z.-P., Liu, J., Chen, J., Ding, J., Fonseca, R. I., Barreto-Chaves, M. L., Donato, J., Hu, X., Wang, D.-Z. Tags: PublishAheadOfPrint Source Type: research