Effect of PTCH1 expression on placental and fetal growth in rats treated with retinoic acid

Objective: Pacthed-1 (PTCH1) suppresses hedgehog signaling. Decreased expression of PTCH1 induces Gli1, a downstream transcription factor, leading to cell proliferation. Retinoic acid (RA) has been reported to induce PTCH1 expression. Since RA administration induce myelomeningocele rat model with low birth weight, we investigated an inhibitory effect on placental and fetal growth by PTCH1 expression due to RA administration to elucidate one of the causes of fetal growth restriction.

Source: Placenta - November 1, 2017 Category: Reproduction Medicine Authors: Kazuhiro Kajiwara Source Type: research