Advanced glycation end products regulate interleukin-1 β production in human and murine placental cells

Preeclampsia and maternal obesity, risk factors for adverse pregnancy complications, results in inflammatory cytokine release in the placenta, including interleukin-1 β (IL-1β), IL-6, and tumor necrosis factor-α. In addition, these pregnant women develop accelerated systemic and placental inflammation with elevated circulating advanced glycation end products (AGE). IL-1β is a pivotal inflammatory cytokine associated with obesity and pregnancy complications, a nd its production is regulated by pyrin domain-containing 3 (NLRP3) inflammasomes.
Source: Placenta - Category: Reproduction Medicine Authors: Source Type: research