Opportunities for therapeutic antibodies directed at G-protein-coupled receptors

Nature Reviews Drug Discovery 16, 787 (2017). doi:10.1038/nrd.2017.91 Authors: Catherine J. Hutchings, Markus Koglin, William C. Olson & Fiona H. Marshall G-protein-coupled receptors (GPCRs) are activated by a diverse range of ligands, from large proteins and proteases to small peptides, metabolites, neurotransmitters and ions. They are expressed on all cells in the body and have key roles in physiology and homeostasis. As such, GPCRs are one
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Review Source Type: research