WD40 repeat domain proteins: a novel target class?

Nature Reviews Drug Discovery 16, 773 (2017).
doi:10.1038/nrd.2017.179

Authors: Matthieu Schapira, Mike Tyers, Maricel Torrent & Cheryl H. Arrowsmith
Antagonism of protein–protein interactions (PPIs) with small molecules is becoming more feasible as a therapeutic approach. Successful PPI inhibitors tend to target proteins containing deep peptide-binding grooves or pockets rather than the more common large, flat protein interaction surfaces. Here, we review one of the

Source: Nature Reviews Drug Discovery - October 13, 2017 Category: Drugs & Pharmacology Authors: Matthieu Schapira Mike Tyers Maricel Torrent Cheryl H. Arrowsmith Tags: Review Source Type: research