Transplantation: Combining OX40L and mTOR blockade

Nature Reviews Drug Discovery 16, 754 (2017). doi:10.1038/nrd.2017.207 Author: Sarah Crunkhorn Controlling alloimmunity after transplantation remains a significant challenge, as existing immunosuppressive agents typically inhibit both effector T (Teff) and regulatory T (Treg) cells. Using the non-human primate graft-versus-host disease (GVHD) model, Tkachev et al. now demonstrate that the combination of
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research