G protein-coupled receptors: Gut feeling on bacterial GPCR agonists

Nature Reviews Drug Discovery 16, 754 (2017).
doi:10.1038/nrd.2017.205

Author: Megan Cully
The mechanisms through which microorganisms in the gut affect human health are poorly defined. Writing in Nature, Cohen and colleagues describe commensal bacterial metabolites that activate G protein-coupled receptors (GPCRs) in the intestine, including GPR119, thereby improving glucose tolerance in mice.In previous work,

Source: Nature Reviews Drug Discovery - October 30, 2017 Category: Drugs & Pharmacology Authors: Megan Cully Tags: Research Highlight Source Type: research