Immunotherapy: CD8+ T cells — burn fat, get fit

Nature Reviews Cancer 17, 635 (2017).
doi:10.1038/nrc.2017.94

Author: Conor A. Bradley
Zhang et al. report that CD8+ tumour-infiltrating T lymphocytes exposed to a hypoglycaemic and hypoxic tumour microenvironment enhance PPARα signalling and fatty acid catabolism to partially preserve effector functions and increase the efficacy of immunotherapy in melanoma mouse models.

Source: Nature Reviews Cancer - October 6, 2017 Category: Cancer & Oncology Authors: Conor A. Bradley Tags: Research Highlight Source Type: research