Targeted therapies: Understanding tumour drug addiction

Nature Reviews Cancer 17, 634 (2017). doi:10.1038/nrc.2017.98 Author: Conor A. Bradley Kong et al. report a mechanism that underlies tumour 'drug addiction' in melanoma cell lines and mouse models involving an ERK2-dependent phenotype switch, which might have clinical implications for the use of alternating treatment strategies with targeted therapies.
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Research Highlight Source Type: research