Clues for early detection of autoimmune Addison's disease – myths and realities

ConclusionThe most consistent biochemical finding of untreated AAD was low sodium independent of the degree of glucocorticoid deficiency. Half of the patients had elevated TSH levels. Only a minority presented with marked hyperkalaemia or other nonhormonal abnormalities. Thus, unexplained low sodium and/or elevated TSH should prompt consideration of an undiagnosed AAD, and on clinical suspicion bring about assay of cortisol and ACTH. Presence of 21‐hydroxylase autoantibodies confirms autoimmune aetiology. Anticipating additional abnormalities in routine blood tests may delay diagnosis.

Source: Journal of Internal Medicine - November 3, 2017 Category: Internal Medicine Authors: Å. B. Sævik, A.‐K. Åkerman, K. Grønning, I. Nermoen, S. F. Valland, T. E. Finnes, M. Isaksson, P. Dahlqvist, R. Bergthorsdottir, O. Ekwall, J. Skov, B. G. Nedrebø, A.‐L. Hulting, J. Wahlberg, J. Svartberg, C. Höybye, I. H. Bleskestad, A. P. Jør Tags: Original Article Source Type: research