Structure –Function Relationship Studies In Vitro Reveal Distinct and Specific Effects of Long‐Chain Metabolites of Vitamin E

ConclusionThe LCM effects depend on the presence of the chromanol ring system and on the modification of the side‐chain but not on the substitution pattern of the chromanol ring. Therefore, it can be concluded that for mediation of effects by LCM the entire molecule is needed and that the effects are specific. We propose the LCM of the micronutrient vitamin E as a new class of regulatory metabolites, but further studies are needed to corroborate this hypothesis.

Cytochrome‐dependent metabolism of vitamin E initially forms long‐chain metabolites (LCM) 13′‐hydroxychromanols (13′‐OH) and 13′‐carboxychromanols (13′‐COOH). A structure–activity relationship study using α‐ and δ‐tocopherol, their 13′‐LCM and representatives of their substructures (α‐carboxyethylhydroxychromanol and pristanic acid) is performed to unravel structural elements required for biological activity. The LCM effects depend on the presence of the chromanol system and the modification of the side‐chain but not on the substitution pattern of the chromanol ring. It can be concluded that for effects the entire LCM molecule is needed and that the effects are specific.

Source: Nahrung / Food - November 3, 2017 Category: Nutrition Authors: Lisa Schm ölz, Maria Wallert, Nicolò Rozzino, Andrea Cignarella, Francesco Galli, Michael Glei, Oliver Werz, Andreas Koeberle, Marc Birringer, Stefan Lorkowski Tags: RESEARCH ARTICLE Source Type: research