Blood –Brain Barrier Permeability of Green Tea Catechin Metabolites and their Neuritogenic Activity in Human Neuroblastoma SH‐SY5Y Cells

ConclusionThe permeability of EGC‐M5 and its conjugated forms into the BBB suggests that they reached the brain parenchyma. In addition, the ability of EGC‐M5 to affect nerve cell proliferation and neuritogenesis suggests that EGC‐M5 may promote neurogenesis in the brain.

To understand the mechanism by which green tea lowers the risk of dementia, metabolites of epigallocatechin gallate (EGCG) are focused on. The in vitro blood–brain barrier permeability of 5‐(3′,5′‐dihydroxyphenyl)‐γ‐valerolactone (EGC‐M5) is 3.7% in 0.5 h. The neuritogenesis of SH‐SY5Y cells is enhanced by EGC‐M5. The metabolite of EGCG, EGC‐M5, may promote neurogenesis in the brain.

Source: Nahrung / Food - November 3, 2017 Category: Nutrition Authors: Keiko Unno, Monira Pervin, Aimi Nakagawa, Kazuaki Iguchi, Aya Hara, Akiko Takagaki, Fumio Nanjo, Akira Minami, Yoriyuki Nakamura Tags: RESEARCH ARTICLE Source Type: research