Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats

This study expands these findings by investigating neural GnRH regulation by melatonin during BDL-induced cholestasis by infusing melatonin into the brain. Melatonin infusion reduced cholangiocyte proliferation and fibrosis, and these effects are due to GNRH receptor 1-dependent paracrine signaling between cholangiocytes and hepatic stellate cells.

Source: AJP: Gastrointestinal and Liver Physiology - November 1, 2017 Category: Gastroenterology Authors: McMillin, M., DeMorrow, S., Glaser, S., Venter, J., Kyritsi, K., Zhou, T., Grant, S., Giang, T., Greene, J. F., Wu, N., Jefferson, B., Meng, F., Alpini, G. Tags: RESEARCH ARTICLE Source Type: research