PARP2 deficiency affects invariant-NKT-cell maturation and protects mice from concanavalin A-induced liver injury
In conclusion, our results suggest that the defect of T-lymphocyte maturation in Parp2 knockout mice leads to a systemic reduction of iNKT cells, reducing hepatocyte death during ConA-mediated liver damage, thus protecting the mice from hepatitis.
NEW & NOTEWORTHY The genetic inactivation of Parp2, but not Parp1, protects mice from concanavalin A hepatitis. Immune cell populations are lower in the thymus, but not in the spleen, liver, or bone marrow of Parp2-deficient mice compared with wild-type mice. Spleen and liver invariant natural killer T (NKT) lymphocytes, as well as thymic T and NKT lymphocytes, are reduced in Parp2-deficient mice.
Source: AJP: Gastrointestinal and Liver Physiology - Category: Gastroenterology Authors: Filliol, A., Piquet-Pellorce, C., Dion, S., Genet, V., Lucas-Clerc, C., Dantzer, F., Samson, M. Tags: RESEARCH ARTICLE Source Type: research
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