The role of Ca2+-activated Cl- current in tone generation in the rabbit corpus cavernosum

In conclusion, although both drugs were effective blockers of IClCa, the effect of T16Ainh-A01 on L-type Ca2+ current precludes its use for evaluating the role of IClCa in tone generation. However, 10 μM CaCCinh-A01 selectively blocked IClCa versus L-type Ca2+ current and reduced spontaneous and PE-induced tone, suggesting that IClCa is important in maintaining penile detumescence.

Source: AJP: Cell Physiology - November 1, 2017 Category: Cytology Authors: Hannigan, K. I., Griffin, C. S., Large, R. J., Sergeant, G. P., Hollywood, M. A., McHale, N. G., Thornbury, K. D. Tags: RESEARCH ARTICLE Source Type: research