aPKC{lambda} maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface

In conclusion, the regulation of SD turnover by aPKC is crucial for the maintenance of SD integrity and defects in aPKC signalling can lead to proteinuria. These findings not only reveal the pivotal importance of the dynamic turnover of cell-surface SD components but also suggest a novel pathophysiological basis in glomerular disease.

Source: Journal of Biochemistry - July 28, 2014 Category: Biochemistry Authors: Satoh, D., Hirose, T., Harita, Y., Daimon, C., Harada, T., Kurihara, H., Yamashita, A., Ohno, S. Tags: Regular Papers Source Type: research