Cancer and Autoimmunity: Paraneoplastic Neurological Disorders Associated With Neuroblastic Tumors

Cancer and autoimmunity come together in paraneoplastic syndromes (PNS), which reflect the remote, not direct, effects of cancer. In the pediatric population, a variety of PNS have been described, but the most common of these rare disorders are instigated by neuroblastic tumors, such as neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. The main pediatric-onset neurological PNS are ROHHAD syndrome, anti-ANNA1 (anti-Hu), and opsoclonus-myoclonus syndrome. They manifest distinctive neurological features, which aid the diagnosis, though under-recognition still poses serious challenges and risks.

Source: Seminars in Pediatric Neurology - September 1, 2017 Category: Neurology Authors: Wendy G. Mitchell, Franz Blaes Source Type: research