Establishment of an alternative efficiently genotyping strategy for human ABO gene

ABO genotyping is frequently used in clinical examinations [1] and forensic investigations [2]. The most commonly used typing methods are serological methods, which are based on hemagglutination reactions against specific antisera. In most circumstances, serological methods are reliable and efficient for routine examinations, but they have several shortcomings, such as antigen activity competition, individual secretion state and microbial contamination [3]. In recent years, researchers have turned their attentions to molecular typing methods; these are based on using the information of DNA polymorphisms and mutations among different blood group antigens to predict the possible blood type.
Source: Legal Medicine - Category: Forensic Medicine Authors: Source Type: research