IgG subclasses' response to a set of mycobacterial antigens in different stages of Mycobacterium tuberculosis infection

Despite the reported high heterogeneity of the human immune response to tuberculosis (TB), new studies may contribute to the understanding of Mycobacterium tuberculosis immunopathogenesis. To investigate the patterns of humoral response during latent (LTBI) and active TB, we evaluated specific IgG subclasses' response, by ELISA, to a set of mycobacterial antigens (Rv2029c, Rv2031c, Rv2034, Rv2628, Rv3353c ESAT6:CFP10, and the new chimeric PstS1(285-374):CFP10) in plasma samples from exposed uninfected controls (ExC, n  = 24), LTBI (n = 61), and TB (n = 15) donors.

Source: Tuberculosis - October 31, 2017 Category: Respiratory Medicine Authors: Leonardo Silva de Araujo, Nidai de B árbara Moreira da Silva, Janaina Aparecida Medeiros Leung, Fernanda Carvalho Queiroz Mello, Maria Helena Féres Saad Tags: Immunological Aspects Source Type: research