Behavioural and computational methods reveal differential effects for how delayed and rapid onset antidepressants effect decision making in rats

Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders. Until the recent discovery of the rapid onset antidepressant action of ketamine, pharmacological treatments for MDD were limited to conventional antidepressant drugs with delayed clinical efficacy. Using a judgement bias task, this study has investigated whether the temporal differences observed in patients would be reflected in affective biases and decision making behaviour in rodents. The diffusion model was also used to investigate the underlying decision making processes.
Source: European Neuropsychopharmacology - Category: Psychiatry & Psychology Authors: Source Type: research