KH-type splicing regulatory protein is a new component of chromatoid body

In this study, we showed that KSRP partly localizes in CB, as a component of CB. KSRP interacts with proteins (mouse VASA homolog (MVH), polyadenylate-binding protein 1 (PABP1) and polyadenylate-binding protein 2 (PABP2)), mRNAs (Tnp2 and Odf1) and microRNAs (microRNA-182) in mouse CB. Moreover, KSRP may regulate the integrity of CB via DDX5-miRNA-182 pathway. In addition, we found abnormal expressions of CB component in testes of Ksrp-knockout mice and of patients with hypospermatogenesis. Thus, our results provide mechanistic insight into the role of KSRP in spermatogenesis.

Source: Reproduction - October 31, 2017 Category: Reproduction Medicine Authors: Zhang, H., Wang, G., Liu, L., Liang, X., Lin, Y., Lin, Y.-Y., Chou, C.-F., Liu, M.-F., Huang, H., Sun, F. Tags: Research Source Type: research