Letter re: Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease

Ng et al.1 reported that Neuropsychiatric Inventory (NPI) scores predict hypometabolism in the posterior cingulate cortex (PCC) in preclinical Alzheimer disease (AD) with PCC hypermetabolism at baseline preceding hypometabolism 2 years later. Early and progressive hypometabolism/atrophy of the PCC in AD is a well-established finding,2,3 but early hypermetabolism is more difficult to reconcile with current network-based models of neurodegeneration. Whether it is suitable to classify groups according to average metabolic changes in the same regions that emerge in subsequent analyses (e.g., orbitofrontal, PCC) is unclear.

Source: Neurology - October 30, 2017 Category: Neurology Authors: Landin-Romero, R., Kumfor, F. Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research