What can DTI tell about early cognitive impairment? – Differentiation between MCI subtypes and healthy controls by diffusion tensor imaging

Mild cognitive impairment (MCI) gained a lot of interest recently, especially that the conversion rate to Alzheimer Disease (AD) in the amnestic subtype (aMCI) is higher than in the non-amnestic subtype (naMCI). We aimed to determine whether and how diffusion-weighted MRI (DWI) using the diffusion tensor model (DTI) can differentiate MCI subtypes from healthy subjects. High resolution 3D T1W and DWI images of patients (aMCI, n=18; naMCI, n=20; according to Petersen criteria) and controls (n=27) were acquired at 3T and processed using ExploreDTI and SPM.

Source: Psychiatry Research: Neuroimaging - October 30, 2017 Category: Psychiatry Authors: Gyula Gyebn ár, Ádám Szabó, EnikO SirAly, Zsuzsanna Fodor, Anna Sákovics, Pál Salacz, Zoltán Hidasi, Éva Csibri, Gábor Rudas, Lajos R. Kozák, Gábor Csukly Source Type: research