Tri-allelic patterns of STRs and partially homologous non-sister chromatid crossover observed in a parentage test

In the parentage test using STR typing, detection of tri-allelic pattern in a locus suggests the copy number variations (CNVs) or trisomy. However, it is difficult to identify whether the pattern was caused by CNVs or trisomy. Trisomy is caused by Robertsonian translocation, reciprocal translocation, inverted duplication of chromosome, recombinant duplication of chromosome resulted by ring chromosome or parental inverted, and partial duplications [1]. CNVs are caused by structural rearrangements of the genome including translocations, duplications, inversion, and deletions [2].

Source: Legal Medicine - October 28, 2017 Category: Forensic Medicine Authors: Huiyong Jiao, He Ren, Yaran Yang, Bin Ni, Haiyan Zhou, Wei Chen, Yunwang Cao, Chuguang Chen, Yanmei Huang, Jiangwei Yan Tags: Case Report Source Type: research