Synovial Immunophenotype and Anti –Citrullinated Peptide Antibodies in Rheumatoid Arthritis Patients

ConclusionThe results of this prospective study demonstrate that the levels of synovial B cell infiltrates and lymphoid aggregates were significantly higher in ACPA+ RA patients, especially those who were naive to treatment. In addition, ACPA+ subjects developed more erosions during progression of the disease and had higher serum levels of CXCL13. The EULAR response to therapy in ACPA+ RA patients was associated with increased levels of T cell and macrophage markers.

Source: Arthritis and Rheumatism - October 27, 2017 Category: Rheumatology Authors: Carl Orr, Aurelie Najm, Monika Biniecka, Trudy McGarry, Chin ‐Teck Ng, Francis Young, Ursula Fearon, Douglas J. Veale Tags: Original Article Source Type: research