Interleaved 31P MRS imaging of human frontal and occipital lobes using dual RF coils in combination with single ‐channel transmitter–receiver and dynamic B0 shimming

This article presents a simple and effective approach which allows the interleaved measurement of 31P spectra and imaging from two distinct human brain regions of interest with dynamic B0 shimming capability. A transistor–transistor logic controller was employed to actively switch the single‐channel X‐nuclear radiofrequency (RF) transmitter–receiver between two 31P RF surface coils, enabling the interleaved acquisition of two 31P free induction decays (FIDs) from human occipital and frontal lobes within the same repetition time. Linear gradients were incorporated into the RF pulse sequence to perform the first‐order dynamic shimming to further improve spectral resolution. The overall results demonstrate that the approach provides a cost‐effective and time‐efficient solution for reliable 31P MRS measurement of cerebral phosphate metabolites and adenosine triphosphate (ATP) metabolic fluxes from two human brain regions with high detection sensitivity and spectral quality at 7 T. The same design concept can be extended to acquire multiple spectra from more than two brain regions or can be employed for other magnetic resonance applications beyond the 31P spin. Illustration of dual‐coil technique enabling interleaved 31P magnetic resonance spectroscopy (MRS) imaging from human occipital lobe (Coil 1) and frontal lobe (Coil 2) at 7 T with the capability of dynamic B0 shimming to obtain high‐quality three‐dimensional (3D) chemical shift imaging (CSI) data, as ...
Source: NMR in Biomedicine - Category: Radiology Authors: Tags: RESEARCH ARTICLE Source Type: research