Synthesis of Z- or E-Trisubstituted Allylic Alcohols and Ethers by Kinetically Controlled Cross-Metathesis with a Ru Catechothiolate Complex

JacsSynthesis of Z- or E-Trisubstituted Allylic Alcohols and Ethers by Kinetically Controlled Cross-Metathesis with a Ru Catechothiolate Complex: The first examples of kinetically controlled cross-metathesis reactions that generateZ- orE-trisubstituted alkenes are disclosed. Transformations are catalyzed by ≤6.0 mol % of a Ru catechothiolate complex and afford trisubstituted allylic alcohols and ethers in up to 81% yield and>98% stereoisomeric purity.

Source: Organometallic Current - October 26, 2017 Category: Chemistry Tags: Cross metathesis Ru catalyzed Source Type: blogs