Synthesis of ( )-Pancratistatins via Catalytic Desymmetrization of Benzene

JacsSynthesis of ( )-Pancratistatins via Catalytic Desymmetrization of Benzene: A concise synthesis of (+)-pancratistatin and (+)-7-deoxypancratistatin from benzene using an enantioselective, dearomative carboamination strategy has been achieved. This approach, in combination with the judicious choice of subsequent olefin-type difunctionalization reactions, permits rapid and controlled access to a hexasubstituted core.

Source: Organometallic Current - October 26, 2017 Category: Chemistry Tags: Desymmetrization Total synthesis Source Type: blogs