( ‐)‐Epigallocatechin‐3‐gallate Ameliorates Insulin Resistance and Mitochondrial Dysfunction in HepG2 Cells: Involvement of Bmal1

ConclusionThe results demonstrated that EGCG possesses a Bmal1‐dependent efficacy against insulin resistance conditions by strengthening the insulin signaling and eliminating oxidative stress, suggesting that EGCG may serve as a promising natural nutraceutical for the regulation of metabolic disorders relevant to circadian clocks. (‐)‐Epigallocatechin‐3‐gallate (EGCG), the major catechin found in green tea (Camellia sinensis), has shown a wide variety of beneficial effects. This study evinces that EGCG in the regulation of insulin resistance and glycogen synthesis triggered by glucosamine via reprograming the circadian clock and ameliorating mitochondrial function both in HepG2 cells and primary hepatocyte.
Source: Nahrung / Food - Category: Nutrition Authors: Tags: RESEARCH ARTICLE Source Type: research