Epstein-Barr virus DNA load kinetics analysis in allogeneic hematopoietic stem cell transplant recipients: Is it of any clinical usefulness?

Epstein-Barr virus (EBV)-related post-transplant lymphoproliferative disorders (PTLDs) are a feared complication in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) because of its severe clinical course and high mortality rate [1]. Monitoring EBV DNA load in blood by real-time PCR has become a mainstay practice for estimating the risk of an impending PTLD, triggering the implementation of preventative strategies (such as a reduction in immunosuppression or initiation of preemptive therapy with rituximab), and for assessing therapeutic responses in cases of high-level EBV DNAemia or PTLDs [2 –4].
Source: Journal of Clinical Virology - Category: Virology Authors: Tags: Full length article Source Type: research