VGF and its C-terminal peptide TLQP-62 regulate memory formation and depressive behavior via a BDNF-TrkB-dependent mechanism

Regulated expression and secretion of brain-derived neurotrophic factor (BDNF), which activates TrkB receptor signaling, is thought to play a critical role in cognition, depressive behavior, and antidepressant efficacy. Our lab has sought to identify additional modulators of cognitive and depressive behavior that regulate activity-dependent BDNF secretion and/or potentiate TrkB receptor signaling. In the adult hippocampus, expression of the granin family protein VGF and secretion of its C-terminal peptide TLQP-62 are required for fear memory formation and the response to antidepressants, including voluntary exercise, imipramine, and ketamine.

Source: Neuropeptides - October 1, 2017 Category: Neuroscience Authors: Wei-Jye Lin, Cheng Jiang, Masato Sadahiro, Ozlem Bozdagi, Lucy Vulchanova, Scott Russo, Cristina Alberini, Stephen Salton Source Type: research