Role and activation mechanism of the Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel in mouse models of chronic pain

Few contradictory data are available about the activation and pathophysiological relevance of Transient Receptor Potential Ankyrin 1 (TRPA1) in chronic inflammation and pain. Noxious mediators produced by the semicarbazide-sensitive amine-oxydase (SSAO) during tissue injury, such as formaldehyde and methylglyoxal, are its stimulators, but link between TRPA1 and SSAO products, and analgesic effect of SSAO inhibitors have not been investigated. We studied the role of TRPA1, SSAO, and their interactions in chronic pain models.

Source: Neuropeptides - October 1, 2017 Category: Neuroscience Authors: Zsuzsanna Helyes, Balint Scheich, Adam Horvath, Balint Botz, Valeria Tekus, Andrea Czompa, Robert Ludmerczki, Erika Pinter, Janka Csepregi, Janos Szolcsanyi, Attila Mocsai, Peter Matyus Source Type: research