Control of the sympathetic nervous system by TRPV1 in the regulation of body temperature

Transient receptor potential vanilloid 1 (TRPV1) is involved in pain and neurogenic inflammation. It has recently been found that TRPV1 anatgonism causes hyperthermia in multiple species from mice to humans. In the present study, we investigated whether TRPV1 regulates basal sympathetic nervous system (SNS) activity. C57BL6/J wild-type (WT) mice and TRPV1 knockout (KO) mice were implanted with radio-telemetry probes for measurement of core body temperature. AMG9810 (50 mg/kg) or vehicle (2% DMSO/5% Tween 80/10 ml/kg saline) was injected via the peritoneal route.

Source: Neuropeptides - October 1, 2017 Category: Neuroscience Authors: Khadija Alawi, Aisah Aubdool, Lihuan Liang, Elena Wilde, Abhinav Vepa, Paraskevi-Maria Psefteli, Susan Brain, Julie Keeble Source Type: research