Evidence for the role of sphingomyelin and lipid rafts in Ca2+-gating of the Transient Receptor Potential channels in trigeminal sensory neurons and peripheral nerve terminals

Transient Receptor Potential (TRP) cation as the TRP Vanilloid 1 and TRP Ankyrin repeat domain 1 channels (TRPV1 and TRPA1) are nocisensors playing important role to trigger pain. Two “melastatin” TRP receptors as TRPM8 and TRPM3 are also expressed in subgroups of primary sensory neurons. All these cation channels serve as thermosensors and are suitable to be activated also by several exogenous and endogenous chemical ligands. The role of plasma membrane microdomains of lipid rafts was analysed on isolated trigeminal (TG) neurons and TRPV1-expressing CHO cells by measuring agonists-induced Ca2+ transients with ratiometric technique.

Source: Neuropeptides - October 1, 2017 Category: Neuroscience Authors: Éva Szoke, Éva Sághy, Maja Payrits, Zsuzsanna Helyes, János Erostyák, Tibor Jánosi, György Sétáló Tags: S4/3 Source Type: research