Genetic deletion of the Transient Receptor Potential Ankyrin 1 (TRPA1) receptor inhibits cuprizon-induced demyelination in mice

Multiple sclerosis (MS) is a neurodegenerative disease with inflammation and demyelination. Administration of cuprizone to mice induces primary oligodendroglial apoptosis, secondary demyelination with macrophage invasion and astrocytosis particularly in the corpus callosum. Since the presence of functional TRPA1 receptors has been detected in astrocytes, we investigated the role of this receptor in a cuprizone-induced experimental demyelination model.

Source: Neuropeptides - October 1, 2017 Category: Neuroscience Authors: Eva Saghy, Kata Bolcskei, Acs Peter, Komoly Samuel, Aniko Perkecz, Balazs Gaszner, Eva Sipos, Eva Szoke, Agnes Kemeny, Sandor Zoltan, Zsuzsanna Helyes, Erika Pinter Source Type: research