Sites of CGRP release and actions in the trigeminovascular system

Attacks of primary headaches are accompanied by the release of the potent vasodilator calcitonin gene-related peptide (CGRP) from activated meningeal afferents which may increase intracranial blood flow. We aimed to localize the sites of CGRP release in an in vivo rodent preparation and to record simultaneously meningeal and medullary blood flow.

Source: Neuropeptides - October 1, 2017 Category: Neuroscience Authors: Karl Messlinger, Christine Will, Michael Fischer, M ária Dux Source Type: research