Evaluation of the CGRP Neutralizing Antibody LY2951742 for the Treatment of Migraine and Osteoarthritis Pain
Calcitonin gene-related peptide (CGRP) is a potent vasodilator, but also has well established roles in neurogenic inflammation and nociception. Multiple pieces of evidence support the role of CGRP in migraine including the elevated plasma CGRP levels during migraine attacks, the induction of migraine attacks by CGRP infusion and the clinical efficacy of CGRP receptor antagonists and CGRP antibodies. The role of CGRP in osteoarthritis (OA) pain has been suggested by studies showing increased expression of CGRP containing nerves in painful OA joints, increased CGRP levels in the plasma and synovial fluid of OA patients and the efficacy of CGRP recpetor antagonists and CGRP neutralizing antibodies in preclinical models of OA pain.
Source: Neuropeptides - Category: Neuroscience Authors: Kirk Johnson, Vladimir Skljarevski, Qi Zhang, Margaret Ferguson, Tina Oakes, James Martinez, David Monteith, Yan Jin, Claire Smith, Mark Chambers, Miles Siegel, Robert Benschop, Aaron Schacht Source Type: research