Angiotensin II as a trophic factor mediating sensory axon sprouting and hypersensitivity in inflammatory pain

Inflammation is often accompanied by persistent hypersensitivity, and studies in humans and animals show abnormally increased sensory innervation density. We showed previously that dorsal root ganglion (DRG) neurons express angiotensin II (ANGII) AT2 receptors that mediate axon sprouting. Using overexpression we show that AT2 levels determine the extent of axon outgrowth, and we have dissected the local inflammatory renin-angiotensin system (RAS) to better understand its role in inflammatory hyperinnervation.

Source: Neuropeptides - October 1, 2017 Category: Neuroscience Authors: Peter Smith, Anuradha Chakrabarty, Ying Mu, Aritra Bhattacherjee, Zhaohui Liao Source Type: research