Anticonvulsant effects of a galanin receptor 3 (galr3) antagonist SNAP 37889 in mouse models of seizures

Galanin is widely considered an endogenous anticonvulsant by virtue of its inhibitory effects on excitatory neurotransmission. Although the anticonvulsant activity of galanin is ascribed to the activation of central GalR1 and GalR2 receptors, the role GalR3 in the control of neuronal excitation remains unknown. The distinct localization of GalR3 mRNA in the regions critical for seizure activity suggests the potential modulatory role for GalR3 in neurotransmission. In the absence of selective agonists for GalR3, specific antagonists offer a promising tool to understand the contribution of GalR3 in various physiological and pathological events.

Source: Neuropeptides - October 1, 2017 Category: Neuroscience Authors: Saurabh Gagangras, E. Jill Dahle, Kyle Thomson, Luiyin Zhang, Cameron Metcalf, Grzegorz Bulaj, H. Steve White Source Type: research