Galanin protects brain from ischemic injury of mice following ischemic stroke via inhibition of Caspase-3-dependent apoptosis

The neuropeptide galanin (GAL) may play a role in many pathophysiological processes, including neuroprotection. However, the role of GAL in ischemic stroke is still controversial. Here, the mouse model of middle cerebral artery occlusion (MCAO)/reperfusion was used to explore GAL's effects on ischemic stroke and its underlying mechanisms. A significant decrease of the infarct area and neurological deficits was observed after intracerebroventricular (i.c.v.) administration of 5 pmol GAL. A similar effect was observed in the in vitro oxygen glucose deprivation (OGD) model, in which GAL protected neurons in a dose dependent manner with an IC50 of 10-7 M.
Source: Neuropeptides - Category: Neuroscience Authors: Source Type: research