Identification of functional non-coding transcribed sequences in Eukaryotes species

The physiological consequences of expansion and contraction of protein coding gene families and nucleotide substitutions within these sequences have long been the primary target of most evolutionary studies. However, protein-coding sequences represent about 1% of the functional sequences of our genome, the other 7% of constrained sequences being comprised of both transcribed and non-transcribed non-coding sequences. Recently tens of thousands of long non-coding RNAs (lncRNAs) have been annotated across the eukaryotes, and are generally believed to regulate protein-coding gene expression.

Source: Neuropeptides - October 1, 2017 Category: Neuroscience Authors: Wilfried Haerty, Chris Ponting Source Type: research