Expression and inflammation-induced alterations of Transient Receptor Potential Vanilloid 1 (TRPV1) and Ankyrin 1 (TRPA1) ion channels in the human gastric mucosa

The importance of sensory-immune interactions in gastritis has recently been emphasized with special focus on Transient Receptor Potential Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) ion channels. They are mainly localized on capsaicin-sensitive sensory nerves, activated by several spices and inflammatory substances, and mediate thermo and pain sensation, neurogenic inflammation. Since their presence on several non-neuronal cells is well-described but their functional relevance is unknown, we investigated TRPV1 and TRPA1 expressions in the human gastric mucosa at mRNA and protein levels, as well their alterations in gastritis.

Source: Neuropeptides - October 1, 2017 Category: Neuroscience Authors: Kata Cseko, Balint Szalontai, Krisztina Pohoczky, Ivett Hegedus, Aniko Perkecz, Anita Illes, Aron Vincze, Jozsef Czimmer, Imre Szabo, Zsuzsanna Helyes Source Type: research