The role of Transient Receptor Potential Ankyrin1 receptor in β-amyloid1-42-induced cholinergic neurodegeneration in the basal forebrain

Background: Alzheimer's disease (AD) is a neurodegenerative condition causing severe dementia. The basal forebrain cholinergic (BFC) neurons play essential roles in memory and learning, they are highly affected in AD. The undegradable β-amyloid oligomer plaques cause neuronal damage in the substantia innominata-nucleus basalis magnocellularis complex (SI-NBM) and somatosensory cortical projection areas of the BFC neurons.
Source: Neuropeptides - Category: Neuroscience Authors: Source Type: research