Lack of pro-algesic effect of polysulfide compound dimethyl trisulfide and Cav 3.2 calcium channles in mild heat injury-induced mechanical hyperalgesia in mice

Polysulfides activate TRPA1 receptors of sensory neurons that are involved in mechanical hyperalgesia. Activation of sensory neurons might cause somatostatin (SOM) release. SOM works analgesic via sst4 receptors. CaV 3.2 calcium channels participate in hydrogen sulfide-induced pain. We wished to examine the effect of polysulfide-driven TRPA1 activation on mechanical hyperalgesia focusing on the roles of sst4 receptors and CaV 3.2 calcium channels.

Source: Neuropeptides - October 1, 2017 Category: Neuroscience Authors: Gabor Pozsgai, Reka Sebestyen-Batai, Elise Steen, Zsuzsanna Helyes, Erika Pinter Source Type: research