NAX 810-2, A Novel Galanin-Based Therapy for Epilepsy

The endogenous neuropeptide galanin and its associated receptors play an important role in the control of seizures and are therefore an attractive therapeutic target. However, developing neuropeptides as therapeutics has been challenging due to poor metabolic stability and lack of blood-brain barrier penetration. Furthermore, activation of peripheral GalR1 receptors results in hyperglycemia due to inhibition of insulin release. We have applied a novel technology platform to develop galanin analogs that are metabolically stable, maintain low nanomolar affinity for galanin receptors, and following systemic administration are potently active in preventing induced seizures.
Source: Neuropeptides - Category: Neuroscience Authors: Source Type: research