The galanin receptor 3 antagonist SNAP 37889 induces apoptosis in vitro

Galanin and its receptors (GAL1-3) modulate a range of neuronal, immune and vascular activities. In vivo administration of SNAP 37889 a potent small non-peptidergic antagonist of GAL3, reportedly reduces anxiety- and depression-related behavior in rodent models. Accordingly, SNAP 37889 has been proposed as a potential therapeutic agent to treat anxiety and depression related disorders. Therefore, we evaluated the toxicity of SNAP 37889 to different cell types.

Source: Neuropeptides - October 1, 2017 Category: Neuroscience Authors: Andreas Koller, Raphaela Rid, Marlena Beyreis, Rodolfo Bianchini, Barbara S. Holub, Andreas Lang, Felix Locker, Bernhard Brodowicz, Ognjen Velickovic, Martin Jakab, Hubert Kerschbaum, Kamil Önder, Barbara Kofler Source Type: research