GALR1/GALR2 Knockdown rats block the Depression and Anxiogenic effects induced by GAL(1-15): The Heterodimer GALR1/GALR2 as a target of GAL(1-15)

The Galanin N-terminal fragment(1-15) [GAL(1-15)] induces depressant-and anxiogenic-like actions. In this work, we have studied the role of GALR2 and GALR1 on the effects of GAL(1-15) in the Forced Swimming Test (FST) and Open Field Test (OFT) using siRNA GALR2 and GALR1 knockdown rats.

Source: Neuropeptides - October 1, 2017 Category: Neuroscience Authors: Carmelo Mill ón, Flores-Burgess Antonio, Narvaez Manuel, O Borroto-Escuela Dasiel, Santín Luis, Parrado Concención, Narvaez Jose Angel, Fuxe Kjell, Diaz-Cabiale Zaida Source Type: research